CanCOLD Study

CanCOLD Study

The objectives are to characterize COPD (mild to severe) among a random sample of Canadians, and patient response to disease (link of structural/physiological, clinical variables and health perception) taking into account lifestyle risk factors (not only smoking but subsequent modifiable risk factors), contextual factors (such as age and sex) and associated co-morbidities (cardiovascular diseases, osteoporosis, anxiety and depression, etc).

This will be a great asset to shift from management of a single risk factor (tobacco control) to total COPD risk management. The results of the study will greatly help to assist decision makers in developing policies to improve the diagnosis, the management of COPD and to optimize health care services use.

A total of ~2000 subjects will be sampled, ~1000 men and women, from ≥9 sites. 250 subjects per site will be selected. Sampling will be stratified by sex and stage of the disease:


The CanCOLD team will call upon the population of Canada. 2 000 individuals aged 40+ years will be randomly selected from the prevalence study “COLD”. Selected individuals may accept or refuse to participate.

Consenting persons will answer a health questionnaire and meet with a health professional (research assistants), who will take various physical measurements, pulmonary function tests, chest x ray (CT Scan) and blood sample. Data will be gathered through largely non invasive measures (weight, height, blood pressure, chest x ray and pulmonary function tests, etc.).


The research protocol of the Canadian Cohort Obstructive Lung Disease has been reviewed by the Research Ethics Board of the Research Institute of the McGill University Health Centre and the respective institution in each province. Each investigator agrees to conduct CanCOLD according to the principles approved by these Boards, including obtaining written consent from participants before starting the evaluation. Information about the content of CanCOLD research examinations is presented to the participants in the text of the corresponding consent form and in a discussion with a trained admitting coordinator. At each examination cycle, questions by the participant and discussion can be done before beginning of the scheduled appointment.

Confidentiality is also ensured (all the data furnished are coded). No information that discloses your identity will be released or published. Neither the participant, nor insurance providers, nor employers, nor any other third party (other than researchers authorized by CanCOLD) will have access to the research data and samples.