CanCOLD Discoveries

CanCOLD Discoveries

Results from CanCOLD studies have been published in the most renowned medical journals in the respiratory field (Lancet Respiratory Medicine, AJRCCM, ERJ, Chest, Thorax, etc.). More than 50 collaborative substudies have been accepted in partnership with academia including the CRRN and others with industry.

2015

Tan, W.C., et al., Characteristics of COPD in never-smokers and ever-smokers in the general population: results from the CanCOLD study. Thorax, 2015. 70(9): p. 822-829.

DOI: http://dx.doi.org/10.1136/thoraxjnl-2015-206938
Key findings:
  • COPD in never-smokers forms a substantial burden in the population: nearly 30% of CanCOLD subjects with COPD had never smoked
  • COPD in never-smokers was more likely to affect women compared with men.
2016

Labonté, L.E., et al., Undiagnosed Chronic Obstructive Pulmonary Disease Contributes to the Burden of Health Care Use. Data from the CanCOLD Study. American Journal of Respiratory and Critical Care Medicine, 2016. 194(3): p. 285-298.

DOI: https://doi.org/10.1164/rccm.201509-1795OC
Key findings:
  • Most subjects with COPD in Canada remain undiagnosed: two-thirds of CanCOLD subjects with spirometrically defined COPD had not been previously diagnosed by a physician.
  • Despite experiencing fewer exacerbations, health care use to treat exacerbation-like events in undiagnosed individuals with COPD is similar to that of diagnosed individuals.
2019

Shorofsky, M., et al., Impaired Sleep Quality in COPD Is Associated With Exacerbations: The CanCOLD Cohort Study. Chest, 2019.

DOI: https://doi.org/10.1016/j.chest.2019.04.132
Key findings:
  • Poor sleep quality in individuals with COPD is associated with risk of symptom-based (dyspnea or sputum change ≥ 48 h) and event-based (symptoms plus medication or unscheduled health services use) COPD exacerbations

Tan WC, et al. The effects of marijuana smoking on lung function in older people. Eur Respir J 2019; 54: 1900826

DOI: https://doi.org/10.1183/13993003.00826-2019
Key findings:
  • Prolonged heavy marijuana smoking increases the risk of COPD and accelerates lung function decline in concomitant tobacco cigarette smokers beyond the effects of tobacco alone