Discoveries

2020

Granularity of SERPINA1 alleles by DNA sequencing in CanCOLD

Gupta, Nisha, et al. European Respiratory Journal, 2020.

Key findings:

  • Alpha-1 antitrypsin deficiency is a genetic disorder associated with COPD
  • 15.5% of CanCOLD participants inherited at least one deficient allele associated with alpha-1 antitrypsin deficiency
  • Only genotypes resulting in severe alpha-1 antitrypsin deficiency are associated with COPD phenotypes

DOI: https://doi.org/10.1183/13993003.00958-2020

2019

Impaired Sleep Quality in COPD Is Associated With Exacerbations: The CanCOLD Cohort Study.

Shorofsky, M., et al., Chest, 2019.

Key findings:
  • Poor sleep quality in individuals with COPD is associated with risk of symptom-based (dyspnea or sputum change ≥ 48 h) and event-based (symptoms plus medication or unscheduled health services use) COPD exacerbations.
DOI: https://doi.org/10.1016/j.chest.2019.04.132

The effects of marijuana smoking on lung function in older people.

Tan WC, et al. European Respiratory Journal 2019; 54: 1900826

Key findings:

  • Prolonged heavy marijuana smoking increases the risk of COPD and accelerates lung function decline in concomitant tobacco cigarette smokers beyond the effects of tobacco alone.

DOI: https://doi.org/10.1183/13993003.00826-2019

2016

Undiagnosed Chronic Obstructive Pulmonary Disease Contributes to the Burden of Health Care Use. Data from the CanCOLD Study.

Labonté, L.E., et al., American Journal of Respiratory and Critical Care Medicine, 2016. 194(3): p. 285-298.

Key findings:
  • Most subjects with COPD in Canada remain undiagnosed: two-thirds of CanCOLD subjects with spirometrically defined COPD had not been previously diagnosed by a physician.
  • Despite experiencing fewer exacerbations, health care use to treat exacerbation-like events in undiagnosed individuals with COPD is similar to that of diagnosed individuals.
DOI: https://doi.org/10.1164/rccm.201509-1795OC
2015

Characteristics of COPD in never-smokers and ever-smokers in the general population: results from the CanCOLD study.

Tan, W.C., et al., Thorax, 2015. 70(9): p. 822-829.

Key findings:
  • COPD in never-smokers forms a substantial burden in the population: nearly 30% of CanCOLD subjects with COPD had never smoked
  • COPD in never-smokers was more likely to affect women compared with men.
DOI: http://dx.doi.org/10.1136/thoraxjnl-2015-206938